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Abnormal methylation of the GSTP1 promoter is also present in acute-chronic hepatitis B liver failure and may have a high predictive value for short-term mortality

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Consistent with this expanding in vivo landscape, additional tumor contexts are now being reported where FSP1 inhibition alone can restrict tumor growth, including chromophobe renal cell carcinoma, where FSP1 inhibition decreased tumor growth substantially in vivo and synergized with GPX4/SLC7A11 perturbation in vitro 81

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