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Sustainable results are achieved with continued use and lifestyle support

Next, body composition and metabolic parameters were examined to determine improvement of metabolic dysfunction with incretin agonism

In Phase 3 clinical trials completed in December 2025, retatrutide produced an average body weight reduction of 28.7% at the highest dose over 68 weeks

Nausea is the most common, and this has been shown to typically resolve over the first weeks of being on the medication

Dosing, Appetite, and Blood Sugar Timeline Appetite suppression improves with dosage, and experiences vary by starting dose and sensitivity