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GT-activated prodrugs and potential nephrotoxicity Gamma-glutamyl transferase being the initial and limiting step in GT-activated prodrugs processing and because GT is highly expressed on the luminal surface of the proximal tubules in the kidney, potential nephrotoxicity could have been a limitation in the usage of this class of compound when administered systematically

Research investigating whether modified lactococcus lactis bacteria can deliver BPC-157 to the GI system shows that the bacteria increases levels of the peptide dramatically in cell culture [13]

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Anaphylaxis: Rare cases of anaphylaxis have been reported following injection