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As a major contributor to global mortality and disability, NDDs are associated with diverse pathological mechanisms, including neuroinflammation, oxidative stress, mitochondrial dysfunction, synaptic impairment, and neuronal loss (Lv et al., 2025)

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Dosing optimization requires experimentation within safe ranges - men typically need 1.5-2mg while women need 0.75-1mg, starting conservatively and adjusting based on response and side effect tolerance