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Although findings from clinical studies are promising, there are concerns that long-term exposure of GLP-1 RAs at supratherapeutic or maximum approved maintenance doses may impair muscle cell differentiation and potentially contribute to the development of sarcopenia, despite their potential to improve muscle metabolism and quality [83, 88]

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Dementia rate was 53% lower in patients randomized to GLP-1 RAs versus placebo from the cardiovascular trials (HR = 0.47)