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The timescale was based on the length of evidence available at the time

Providers typically monitor response over time using symptoms, labs when appropriate, and safety assessments according to clinical guidance

It can be traced back to the idea that those in bigger bodies lack self-control and refinement, says Sabrina Strings, a professor of Black studies at the University of California, Santa Barbara, who studies portrayals of gender, race and bodies

Severe, persistent upper abdominal pain radiating to the back, worsening after eating, accompanied by nausea, vomiting, and fever are key warning signs requiring immediate medication discontinuation and emergency evaluation

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