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From 2019 to 2023, the number of prescriptions spiked by more than 400%, while gross spending soared by more than 500%

Retatrutide has attracted attention because clinical trial results have shown significant weight loss in people with obesity or overweight

Typical Dosing Schedules Your doctor will map out a specific plan for you, but it helps to know what a standard progression looks like

Certain side effects have been reported in clinical trials, including gastrointestinal discomfort and allergic reactions

Additional information Peer review information Nature Metabolism thanks Dominique Langin and the other, anonymous reviewers for their contribution to the peer review of this work