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Numerous studies have identified abnormal alterations in various cytokines in the CSF and peripheral blood of SZ patients (see Table 3 ), most of which are pro-inflammatory cytokines (IL-1, IL-2, IL-8, TNF-, and IFN-) (188191), with a smaller proportion being anti-inflammatory cytokines (including TGF-1, IL-4, and IL-10) (192)
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In addition, activation of T cells in the context of Th1-polarizing and Th17-polarizing requirements with the GLP-1RA liraglutide led to reduced differentiation of Th1 and Th17 cells, while there was no observable change in the number of Tregs [145]
Intervention groups knew they were receiving the supplements, which puts the study at a huge risk for bias
For once-daily preparations like liraglutide (Victoza, Saxenda), if a dose is missed and more than 12 hours have passed, the missed dose should be skipped and the next dose taken at the usual time the following day
