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[2] Patients should also seek medical review if constipation significantly impacts quality of life or if they find themselves increasingly reliant on stimulant laxatives
However, fluoxetines long half-life and relatively forgiving pharmacokinetics mean that modest shifts in absorption timing are unlikely to produce clinically significant changes in its therapeutic effect
doi: 10.1073/pnas.2101718118 43 CircuM
The NICE guidelines on obesity management emphasise the importance of ongoing support and monitoring for people taking weight management medications
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