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Dysregulation of UPS in Huntingtons Disease HD patients manifest polyQ repeats of over 40 residues within the N-terminus of huntingtin protein

The D 1 and D 5 dopamine receptors are coupled to the activation of G s -type G-proteins and, therefore, receptor activation results in activation of adenylate cyclase

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ChIP (chromatin immunoprecipitation) assay ChIP assays were performed using EZ-Magna ChIP Chromatin Immunoprecipitation Kit (Millipore), as described previously 78,81

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