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In HCC driven by obesity and nonalcoholic steatohepatitis, the downregulation of CPT2 leads to the accumulation of acylcarnitines, among which C18:1-carnitine enhances spheroid formation by HCC cells through STAT3 activation, indicating that the accumulation of acylcarnitine can promote the development of liver cancer [212]
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P 1,500 mg/day were more effective than lower doses
Addressing these limitations through systematic reviews, meta-analyses, and well-structured clinical trials is essential to establish M
intravenous TB-4 Phase 1 safety and pharmacokinetics, no dose-limiting or serious adverse events (Ann N Y Acad Sci 2010;1194:223229): NCT00743769 Centers for Disease Control and Prevention
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