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In case that as shown earlier these proteins facilitate the uptake of self cfDNA into pDCs and monocytes (239) and thereby potentiate its immunogenic potential to trigger pro-inflammatory effects through the TLR9 pathway (351), the net outcome of treating severe COVID-19 patients at the later stages of the disease with LL-37 might be fatal, as SARS-CoV-2 infection has significantly declined, while the inflammatory response escalates dramatically, becoming predominant (67)

doi: 10.3390/antiox9060518 189 MeftahiG

The stress response system also comes under DSIPs influence