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When these compounds were tested in INS-1 832/3 beta cells 21 with a prolonged incubation to mimic in vivo drug exposure, we found that compounds exhibiting higher internalization also had reduced maximal insulin release (Fig

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Over 43% of menopausal women have obesity, and about 20% of women gain 10 pounds or more during the menopause transition, which can also increase the risk for insulin resistance

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