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Reviewing the team's patent and related documents at Talpos's request, Anna Mapp, the Edwin Vedejs Collegiate Professor of Chemistry at the University of Michigan, and also the President of the American Peptide Society, questioned the limited detail available and the absence of a published sequence for the peptide's parent protein, an omission she noted makes the original work impossible to reproduce

Furthermore, the study demonstrated that the addition of growth hormone to BPC 157-treated fibroblasts activated Janus kinase 2 (JAK2), a key downstream signaling molecule in the GH receptor pathway

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