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Blocks NNMT in fat cells In 3T3-L1 mouse fat cells, 30 M of 5-Amino-1MQ for 24 hours strongly lowered 1-MNA levels direct proof of NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)
Long-term GH elevation also carries theoretical cancer concerns, as GH and IGF-1 can promote cell growth
doi: 10.1021/acs.molpharmaceut.1c00280
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