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A similar situation was observed in rbohD mutants of Arabidopsis, also exhibiting decreased apoplastic localization ( Figure 2 )
The reduced secretion of gastric acid and pepsin produced by PPIs can reduce absorption of protein-bound (dietary) vitamin B12, but not supplemental vitamin B12
N-acetylcysteine (NAC) is a glutathione precursor that the body can use to produce glutathione naturally and has better absorption than oral glutathione
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Published data suggests up to 2.6% incidence of B12 deficiency within a year of treatment, and this figure climbs in patients who have used these medications long term or combined them with very low calorie diets (3)
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