Obes (Silver Spring Md)
Constipation occurs because prolonged colonic transit time increases water absorption from stools, making them harder and more difficult to pass
improves with slower dose escalation Vomiting, diarrhea, or constipation Bloating, heartburn, or stomach discomfort Reduced appetite and early fullness Fatigue or headache Less common side effects Injection-site reactions Fatigue or changes in taste Temporary mild hair thinning (limited evidence) Serious but rare risks Pancreatitis seek care immediately if you experience severe abdominal pain Gallbladder disease or gallstones Kidney complications, particularly from dehydration Thyroid C-cell tumor risk in patients with medullary thyroid cancer history or MEN2 Low blood sugar when combined with insulin or sulfonylureas Contact your provider immediately if you experience severe or persistent abdominal pain, constant vomiting, signs of dehydration, yellowing of the skin or eyes, or symptoms of low blood sugar
For many people with BMI 30 to 40, GLP-1 medications now offer a non-surgical alternative with meaningful results
Transition Gradually, Not Abruptly Instead of stopping cold turkey, consider a gradual taper