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Integrated mechanistic axis: the macrophageMitoROS axis Increasing evidence indicates that RIRI progression is driven, at least in part, by a self-amplifying pathological loop that centers on the interplay between mitochondrial dysfunction, oxidative stress, and macrophage-mediated inflammation

* Correspondence: Ivana arac, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

In recent years, standards of care have shifted to favor LEV for anti-seizure treatment in GBM, and this has its own association with anti-cancer effects (Roh et al., 2020)

Timing also plays an important role

The absence of these protective effects in SIRT1-knockout mice confirms the mechanisms specificity (95)