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Hypoglycemia represents another potential risk, primarily in patients taking tirzepatide in combination with insulin or sulfonylureas

But your new normal may also include being more active

Younger patients with more collagen production tend to see better skin retraction, while those who lose large amounts of weight quickly or have been overweight for many years may notice more pronounced looseness

For a data synthesis comparing lean mass versus fat mass outcomes per compound, including Phase 2 body composition data, see GLP-1 and lean mass loss: what the clinical data shows

No significant long-term risks have been identified in published research