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The number of reactions to sulfites is thought to have been overestimated as some of these asthmatic reactions are likely due to other components in wine

It's native to the Mediterranean and was used earliest by Roman Emperors who consumed Licorice in liquid form

It arises from dysregulation of cell proliferation and concomitant genomic modifications ( Quercetin (QUE) is a flavonol compound that is insoluble in water but soluble in alcohol and lipids ( in vitro and in vivo studies have demonstrated the effects of QUE in cancer treatment

(PubMed) McCann JC, Hudes M, Ames BN