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These osteoclast defects appear to be cell-autonomous, as they could be recapitulated by culturing osteoclast precursors from the global IGF-I KO mice, which showed reduced ability to differentiate into mature osteoclasts (65)
Peptide therapy is not intended to diagnose, treat, cure, or prevent any disease and should not replace evaluation or treatment by a licensed medical professional
Dodsonw L, Sachan DS, Krauss S, Hanna W: Alterations of serum and urinary carnitine profiles in cancer patients: hypothesis of possible significance
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