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Others: Roche, J&J, Sanofi, and AZ have had GLP-1 efforts (some deprioritized) or new dual/triple agonists in development (e.g., Roches pipeline includes a dual agonist announced in 2024)

This limitation is especially important in PCOS, where improved natural conception may plausibly reflect restoration of ovulatory opportunity after weight loss rather than a direct fertility-enhancing effect of the drug itself

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Losses through vomiting can disrupt acid-base balance

Some people refer to it informally as a triple hormone treatment, although it is not currently a licensed medicine