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Clin Endocrinol (Oxf) 2016;84(6):851-7

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Novo Nordisk denies a causal connection between its semaglutide drugs and NAION and has not amended product labeling to include vision loss warnings

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52,53 In a phase 2, multi-center trial conducted at 45 centers, orforglipron at doses of 12 mg or greater showed significant reductions in HbA1c and bodyweight compared with placebo or dulaglutide

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