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Animal experiments have shown that mice inoculated with lung cancer A549 cells treated with IGF-1 LR3 (0.2 mg/kg/d) showed a 2-fold increase in the number of lung metastatic nodules and a 30% reduction in survival time

[19] [21] The compounds targeted in this manner by GSTs encompass a diverse range of environmental or otherwise exogenous toxins, including chemotherapeutic agents and other drugs, pesticides, herbicides, carcinogens, and variably-derived epoxides

Winkler, B

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While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control