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Furthermore, loss of immunoreactivity to APE1 was observed in spinal cords of pre-symptomatic SOD1 G93A mice, suggesting that reduced levels of APE1 in motor neurons precede neurodegeneration (Manabe et al., 2001

Atrophic scars, like an icepick, train unit, and moving scars, result from a collagen deficiency during the recuperating system

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Importantly, microglia in this activated state also secrete pro-inflammatory cytokines such as TNF-, IL-1, and IL-6, which further amplify ROS production and reinforce the inflammatory state