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The cardiovascular outcome data alone, covering nearly 100,000 patients in randomized trials, places this class among the most impactful drug discoveries in modern preventive medicine
Lasting progress usually comes from combining that biological support with consistent routines and practical tools that translate physiology into daily actions
While the medication does not directly cause muscle weakness through a neuromuscular mechanism, the combination of fatigue, gastrointestinal symptoms, rapid weight loss, and dietary changes associated with semaglutide therapy creates a clinical context where weakness can reasonably occur as a secondary phenomenon