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What they did: A two-phase study, first in a dish with human endothelial cells (HUVECs), then in a live rat with an ischemic limb (= they closed off the artery so that no blood reached the leg)
Its efficacy was evaluated in a clinical trial (NCT02193334) in patients with acute SCI, with encouraging motor functional recovery (Nagoshi et al., 2020)
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This comparison examines how these structurally related peptides diverge in mechanism, clinical evidence, safety, and regulatory standing
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