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Quick Answer Neither compound is objectively "better." Available studies indicate MOTS-c is a naturally occurring mitochondrial-derived peptide that optimizes whole-body metabolic function and insulin sensitivity

Saline (0.9% sodium chloride) is another option sometimes mentioned, but it can occasionally cause peptide aggregation or affect solubility, depending on the specific amino acid sequence

FOXO4-DRI theoretically has higher selectivity by targeting the FOXO4-p53 interaction that is specifically elevated in senescent cells