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Interestingly, recently it was shown that stereotaxic injection at the level of SN of the potent ER stressor tunicamycin, an inhibitor of the first steps of the N -glycosylation pathway, can be used as a stress rodent model for PD ( Immune System and Parkinsons Disease Besides mitochondrial impairment and oxidative stress, activation of glial cells and neuroinflammation also play an important role in the progression of the neurodegenerative process in PD (Hirsch et al., 2003

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