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On the contrary, a subsequent randomized phase 2 trial investigated the receipt of eltrombopag during standard induction therapy in AML patients and found no clinical benefit of eltrombopag but rather a tendency for increased severe adverse events (164)

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they can advise whether it should be discarded based on the specific formulation's known stability data and the IMP excursion management protocol Do not use the product if it shows any visual signs of degradation (see previous section) Avoid repeated temperature cycling do not assume the product is safe simply because it has been returned to the fridge