This is uncommon, but it is a reason to address a deficiency before it progresses
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Special Precautions
News Release October 26, 2010 ConsumerLab.com reports deficiencies in some B-complex supplements and more caffeine than expected in "shot-sized" B vitamin "energy" drinks White Plains, New York October 26, 2010 Tests of B vitamin supplements, including B-complexes and shot-sized energy drinks, revealed problems with the quality of 4 out of 18 products selected for review by independent testing organization ConsumerLab.com
Peptides with cysteine, methionine, tryptophan, aspartic acid (Asp), glutamine (Gln), or N-terminal glutamic acid (Glu) are less stable and should be frozen when not in use