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In practice, the long-acting GLP-1 RAs became preferred for general glycemic control due to convenience and greater A1c reduction, whereas short-acting ones like lixisenatide found a niche in combination products or for targeting post-meal glucose excursions (for instance, some use lixisenatide mainly to handle breakfast hyperglycemia)

In a pediatric clinical trial, anti-liraglutide antibodies were detected in 14 (12%) of 117 SAXENDA-treated patients with a post-baseline assessment

These effects typically fade with time, and your provider will guide you on how to minimize discomfort during your treatment

For Constipation: Get enough fiber

However, those seeking convenience and needle-free treatment may prefer Rybelsus