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Metformin was associated with reduced stroke ( P = .032) and reduced all-cause mortality ( P = .021)

Peer review Peer review information Nature Reviews Cardiology thanks Naveed Sattar, Muhammad Shariq Usman and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Across the dose groups studied (1 mg, 4 mg, 8 mg, and 12 mg weekly subcutaneous doses), nausea rates varied according to the dose administered and the speed of dose escalation

These findings are consistent with other studies, like one that compared IGF-1 levels between 28 vegans and 28 members of the Calorie Restriction Society

Effects can last 1-4 weeks depending on your individual metabolism and B12 levels