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6,14 Furthermore, GLP-1 signaling indirectly enhances and restores the insulin signaling pathway in neurons, leading to a reduction in the phosphorylation of insulin receptor substrates and the burden caused by monomeric -synuclein

The difference is mechanism and magnitude

Eli Lilly has reported phase 3 data for orforglipron in its ATTAIN trial update, and AstraZeneca has advanced its candidate following midstage results reported in industry coverage

They do not require a medical prescription and do not replace a treatment prescribed by a specialist doctor

In contrast, patients prescribed this medication without a type 2 diabetes diagnosis are younger (average age of 47.5), more likely to be commercially insured (90.6%) and female (74.7%)