This phenomenon is clearly observed in the STEP 2 trial of semaglutide (2.4 mg weekly), where a cumulative 33.7% of patients with obesity and T2D reported nausea throughout the duration of the trial ( It has been hypothesized that the deleterious, nauseating effects of GLP-1R agonists and the beneficial, food-intake reducing effects are inextricably linked
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Additionally, other issues, like liver disease, might become aggravated by fluctuating thyroid hormone levels, even when the liver cells are capable of handling their own levels of oxidative stress
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