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Dimerization and antidepressant recognition at noradrenaline transporter
[14] [15] A proportionate assessment should be conducted, avoiding unnecessary investigations while remaining vigilant for 'red flags' that might suggest alternative diagnoses (such as persistent joint swelling, unexplained weight loss, night pain, fever, or focal neurological symptoms)
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The SURMOUNT-4 trial showed tirzepatide achieved up to 22.5% weight loss versus 16% for semaglutide at comparable 68-week endpoints, though outcomes overlap significantly depending on dose and individual factors
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