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Alcohol Weakens the LES and increases acid production
In another animal experiment, consumption of an inulin diet increased the level of SCFAs (especially butyrate), which enhanced the host antimicrobial program by inhibiting HDAC3 (78)
The STEP 1 trial (Wilding et al., N Engl J Med, 2021) documented nausea in 44.2% of participants at the 2.4 mg dose versus 17.4% on placebo
Though the weight isnt falling off like water from a Ducks back, I am down 10 lbs over the first 3 weeks, and am motivated by the progress
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