A broader review found it might brighten skin in sun-exposed areas but labeled the overall evidence as "inconclusive" due to mixed study quality (PubMed Systematic Review)
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Mitochondrial targeting of peroxiredoxin 5 is preserved from annelids to mammals but is absent in pig Sus scrofa domesticus
This interaction is particularly relevant in patients at risk for folate deficiency, such as those with malabsorption disorders, chronic alcohol use, or those taking medications that interfere with folate metabolism