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Decades after its discovery, researchers still have not conclusively identified a specific DSIP receptor, and the peptide's precise physiological role remains debated

Cholinesterase inhibitors (donepezil, rivastigmine) - Theoretical complementary mechanisms cholinesterase inhibitors increase acetylcholine while dihexa builds new synapses

Evidence Ledger: What the Research Actually Shows Plain statement: No phase II or III human RCT for BPC-157 in any indication has been published as of May 2026

Traditional capsule and powder forms are often broken down during digestion before meaningful absorption can occur