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The chemical composition interacts with local tissue, and if the pH deviates significantly from physiological norms, it triggers pain receptors and inflammatory mediators

A second unresolved issue is conceptual rather than purely experimental: whether ferroptotic propagation is best understood as transmission of discrete molecular signals or as the spatial crossing of a lipid peroxidation threshold

Whether this translates to humans remains unproven

It is noteworthy that three hybrids out of the eight tested in mice had significantly prolonged duration of action

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