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If you are unable to keep fluids down for more than 24 hours, seek medical evaluation

10.1016/j.pharmthera.2009.06.002

The DRI modification that stabilizes the peptide against degradation also means its elimination kinetics in humans are unknown

This decision requires a healthcare provider who understands your complete medical history, current medications, risk factors, and treatment goals

Similarly, mice exposed to CUMS for 6 weeks showed an increased interferon-gamma (IFN-) and decreased anti-inflammatory IL-10 levels, demonstrating anti-inflammatory suppression with further pro-inflammatory activation (Jia et al., 2024)