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Before taking a B12 shot, tell your doctor if you: Are allergic to B12, cobalt or any multivitamin combinations Have vision issues or Lebers disease (a genetic condition that causes vision loss) Have any infections Have been diagnosed with folic acid deficiency or iron deficiency Are pregnant, breastfeeding, or planning to get pregnant Are taking any supplements, including herbal supplements Are taking any medications, such as folic acid, methotrexate, chloramphenicol, colchicine, para-aminosalicylic acid (PAS), or pyrimethamine Have liver or kidney disease Have a drinking problem RxList