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This legal standoff has not been fully resolved

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Exposure to various environmental stressors, such as tobacco toxins, induces ferritinophagy and ferroptosis in BMSCs, which increases labile iron and ROS, thereby impairing osteoblastic differentiationproviding a mechanistic basis for smoking-associated age-related bone loss (28)

Conclusions This review provides insights into the influence of DPP-4 on bone metabolism and delineates the potential mechanisms of the interaction between DPP-4 and bone (Fig