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The movements that define CrossFit -- olympic lifting, gymnastics, and high-rep metabolic conditioning -- put specific stress on structures that heal slowly
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Beyond simple actin sequestration, Bock-Marquette and colleagues reported in Nature (2004) that T4 activates integrin-linked kinase and Akt, promoting cardiomyocyte and epicardial cell migration and survival in mouse cardiac injury models, which established a signalling role separate from cytoskeletal buffering
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