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Although hepatic accumulation of certain nanomaterials may cause adverse effects, targeted delivery to the spleen and inflammatory foci offers promising immunomodulatory and anti-inflammatory benefits (216)
This is absolutely critical
For example, Ive seen gastrointestinal bleeding from widely approved anti-inflammatory drugs, but Ive never seen it from the peptides BPC-157 or TB-500
This structural manipulation increases receptor availability, and at the same time pharmacodynamic and clearance properties of the molecule are altered
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