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Increase NEAT : Non-exercise activity thermogenesis (walking, standing, cleaning) makes a big difference

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In stroke, reduced mitophagy and autophagy may hinder the prompt clearance of damaged mitochondria in the brain, leading to a loss of protection from increased reactive oxygen species (ROS) and reduced mitochondrial ATP supply (Frugier et al., 2015)

42% of the population is obese, and almost 94% of the population is metabolically dysfunctional in some way