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For drug development, the GLP-1 receptor agonist structure should also be considered, since ligand orientation, peptide modifications, and half-life-extending features directly influence pharmacokinetics and receptor interactions

Lancet Psychiatry 11 , 3646 (2024)

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Expanded coverage under state Medicaid programs could help address these disparities by easing financial burdens and supporting earlier intervention

therefore, these trends may be increasing for all people (not just people with first-time GLP-1 RA prescriptions)