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HGF/c-Met pathway activity declines with age in the hippocampus, paralleling age-related cognitive decline

We previously produced the App NL-G-F/NL-G-F -KI ( App NL-G-F ) mouse strain using genomic DNA of introns 15 to 17 of mouse APP, which humanized the A sequence, and introduced KM670/671NL (Swedish), I716F (Iberian), and E693G (Arctic) mutations 41

The second is when using one MMP-9 level as a baseline, then either provoking it with high-histamine foods, or doing a low-histamine diet, then rechecking