Experimental and therapeutic medicine, 21(2), 125
We have found, by simulation, that if we reduce the amino acid input into the system by 15%, the concentration of GSH and the synthesis rate of GSH are proportionally diminished, but there is little effect on the DNA methylation reaction, while reactions in the folate cycle are reduced by 29%
These include: Nausea Vomiting Diarrhoea Constipation Decreased appetite (which, whilst therapeutically intended, can occasionally be excessive) Injection-site reactions (such as redness, bruising, or discomfort at the injection site) These effects were generally mild to moderate in severity and most frequently occurred during the dose-escalation phase of treatment, tending to diminish over time
SIRT7-mediated modulation of glutaminase 1 regulates TGF--induced pulmonary fibrosis
2019;29(6):1350-62.e7