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Jiang, L

These central effects translate into substantial weight loss - typically 5%-15% of body weight with current GLP-1 RAs - which directly ameliorates hepatic steatosis by reducing adipose tissue mass, reducing hepatic free fatty acid influx, and improving insulin sensitivity

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Ozempic is administered once weekly , and the dose is gradually escalated: Starting dose: 0.25 mg once weekly for 4 weeks (not a therapeutic dose, but for tolerability) Maintenance dose: typically 0.5 mg or 1 mg once weekly Maximum dose: 2 mg once weekly if required for glycaemic control Common errors include taking the medication more frequently than weekly or administering a higher dose than prescribed

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